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However, first-generation EGFR-TKIs generated disappointing response rates in the treatment of HNSCC [5]

10.1001/jama.2016.0783 JAMA

As with any therapy, results vary, and more research is needed before it becomes a mainstream fertility treatment

5.2.2 Limitations due to the disease The pathophysiology of mutations or mechanisms underlying the neuronal pathology of mitochondrial diseases is still unknown in most patients, which makes it difficult to interpret the mitochondrial or neural readout in pharmacological screenings